Current Issue : July- September Volume : 2012 Issue Number : 3 Articles : 4 Articles
Bilayer tablets provide one of the important design approaches where incompatible drugs, with different indication, and same drug with different release rate (e.g. IR and ER) can be incorporated in a single unit, or two incompatible drugs are needed to be provided in single dosage form. Bilayer tablets have several advantages over conventional tablets and few other dosage forms. The formulation and manufacturing of bilayer tablets face many challenges in terms of hardness, delamination, layer thickness and so on. This review highlights the material attributes, formulation design, process parameters that impact the performance, and manufacturability of the bilayer tablets....
In the end of 20th Century and beginning of 21st Century the technology of drug formulation has help the field of pharmacy to the great extend by providing newer technique of controlled release of drug at the site of absorption window thus providing maximum chance of absorption that to with phased manner. Hence, change in the operation is a suitable and optimized way to make the some drug more effective by slight alteration in the drug delivery. Controlled Release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration of the drug in the body. This article contains the basic information regarding controlled release tablet formulation and also the recent evaluation part of the same. The evaluation parameters discussed here are also important as it will help in optimization and standardization of formulation....
The techniques for process control and scale-up of pharmaceutical wet granulation processes are reviewed. For wet granulation in high-shear mixers, specific methods based on the liquid saturation and the consistency of the wet mass are described. Both parameters can be used to quantify the deformability of the wet granules, and relate well with the particle size of the end granules. In practice, the power consumption of the high-shear mixer is used for the monitoring of the wet granulation process, whilst for scale-up, it is helpful to use the underlying relationship between power consumption and saturation level or wet mass consistency. In fluid bed granulation the granulation process is different and the moisture content in the bed is the key parameter to control. This can be monitored directly by near infrared probes or indirectly with temperature probes. As a large number of inter-related variables can be adjusted to modify the process, computerized techniques have become popular for fluid-bed process control – fuzzy logic, neural networks, and models based on experimental design techniques are several examples. In addition, engineering techniques based on particle size population balance modelling are under development for both fluid bed and high-shear granulation....
Oral route of drug administration have wide acceptance up to 50-60% of total dosage forms. Bioavailability and solubility are important in oral dosage forms. Olmesartan medoxomil is an angiotensin II receptor antagonists which lowers high blood pressure. It has low bioavailability and aqueous solubility. The purpose of present investigation was to improve the solubility of Olmesartan medoxomil by solid dispersion and formulation of mouth dissolving tablets to provide quick therapeutic action in the hypertension. Solid dispersions prepared by solvent evaporation method showed solubility enhancement in order of Polyethylene Glycol 4000 ˃ Polyvinylpyrolidone K30 ˃ Poloxamer 188. Solid dispersion of Omesartan Medoxomil with Polyethylene Glycol 4000 in the weight ratio of 1:1 was optimized for preparation of tablets as improved solubility and dissolution rate of Olmesartan Medoxomil compared to pure drug. This binary system was characterized by FT-IR spectroscopy, differential scanning calorimetry and X-Ray diffraction. Optimized solid dispersion showed the presence of amorphous form of drug confirmed by the characterization study. Mouth dissolving tablet of Olmesartan medoxomil based on solid dispersion was prepared by direct compression using different combination of Kyron T-314 and Crospovidone. An optimized formulation F14 had above 90 % cumulative drug release within 3 min, wetting time 20.02 ± 0.03 sec and in-vitro disintegration time 16.61 ± 0.87 sec. Release kinetic model study indicated that all formulations followed Zero order kinetics. Further it was observed that all batches followed constant rate release as per Weibull and Hixson-Crowell model. Stability studies indicated that there were no significant changes in tablet parameters and was stable and reproducible at plant scale....
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